The Cyclin D1 and Cyclin A Genes Are Targets of Activated PTH/PTHrP Receptors in Jansen’s Metaphyseal Chondrodysplasia
نویسندگان
چکیده
منابع مشابه
The cyclin D1 and cyclin A genes are targets of activated PTH/PTHrP receptors in Jansen's metaphyseal chondrodysplasia.
Jansen's metaphyseal chondrodysplasia (JMC) is an autosomal dominant disorder characterized by short-limbed dwarfism, delayed ossification, and hypercalcemia. Activating mutations in the PTH/PTHrP receptor have been identified as the molecular cause of this disorder. Although these mutations have been shown to increase cAMP accumulation, little is known about possible target genes of the downst...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2002
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2001-0103